Gerard J Marek Selected Research

LY 2140023

1/2015	When is a Proof-of-Concept (POC) not a POC? Pomaglumetad (LY2140023) as a Case Study for Antipsychotic Efficacy.
7/2010	LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia.

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Gerard J Marek Research Topics

Disease

13	Schizophrenia (Dementia Praecox) 01/2021 - 01/2007
5	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 04/2002
4	Cognitive Dysfunction 01/2021 - 01/2007
4	Alzheimer Disease (Alzheimer's Disease) 01/2015 - 06/2011
3	Mental Disorders (Mental Disorder) 01/2017 - 04/2007
2	Anxiety Disorders (Anxiety Disorder) 01/2020 - 03/2013
2	Parkinson Disease (Parkinson's Disease) 01/2015 - 06/2011
2	Hallucinations (Hallucination) 03/2010 - 01/2007
2	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 12/2005 - 02/2003
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022
1	Mitochondrial Myopathies (Mitochondrial Myopathy) 01/2022
1	Opioid-Related Disorders (Opiate Addiction) 01/2022
1	Alcoholism (Alcohol Abuse) 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Headache (Headaches) 03/2021
1	Nausea 03/2021
1	Major Depressive Disorder (Major Depressive Disorders) 01/2020
1	Pain (Aches) 01/2019
1	Dementia (Dementias) 01/2015
1	Cushing Syndrome 10/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2013
1	Multiple Sclerosis 06/2011
1	Mood Disorders (Mood Disorder) 04/2007
1	Anhedonia 01/2007

Drug/Important Bio-Agent (IBA)

7	Antipsychotic Agents (Antipsychotics)IBA 01/2021 - 12/2005
6	Glutamic Acid (Glutamate)FDA Link 03/2013 - 04/2002
4	ProdrugsIBA 01/2020 - 03/2010
3	Therapeutic UsesIBA 01/2020 - 12/2005
3	Serotonin (5 Hydroxytryptamine)IBA 06/2012 - 12/2005
2	ASP8062IBA 01/2022 - 03/2021
2	Antidepressive Agents (Antidepressants)IBA 01/2020 - 04/2007
2	Anti-Anxiety Agents (Anxiolytics)IBA 01/2020 - 04/2007
2	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 10/2014
2	Pharmaceutical PreparationsIBA 01/2017 - 06/2011
2	LY 2140023IBA 01/2015 - 07/2010
2	N- (5- (aminocarbonyl)tricyclo(3.3.1.13,7)dec- 2- yl)- alpha,alpha- dimethyl- 4- (5- (trifluoromethyl)- 2- pyridinyl)- 1- piperazineacetamideIBA 10/2014 - 04/2013
2	Dopamine (Intropin)FDA LinkGeneric 06/2012 - 01/2007
2	Ketamine FDA LinkGeneric 04/2012 - 03/2010
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 07/2010 - 04/2007
2	4- aminho- 2- thiabicyclo(3.1.0)hexane- 4,6- dicarboxylic acidIBA 07/2010 - 04/2007
2	Phencyclidine (Angel Dust)IBA 03/2010 - 04/2002
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 12/2005 - 02/2003
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2022
1	Sulfates (Sulfates, Inorganic)IBA 01/2022
1	Dopamine D1 Receptors (Dopamine D1 Receptor)IBA 01/2021
1	EnzymesIBA 01/2019
1	Investigational DrugsIBA 01/2017
1	Biological ProductsIBA 01/2017
1	pomaglumetad methionilIBA 01/2015
1	pimavanserinIBA 01/2015
1	Donepezil (Aricept)FDA LinkGeneric 01/2015
1	ApolipoproteinsIBA 01/2015
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2015
1	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 01/2015
1	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2014
1	Biomarkers (Surrogate Marker)IBA 06/2011
1	metabotropic glutamate receptor 2IBA 07/2010
1	AutoreceptorsIBA 07/2010
1	AmidesIBA 07/2010
1	Methionine (L-Methionine)FDA Link 07/2010
1	Dissociative AnestheticsIBA 03/2010
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 03/2010
1	N-Methylaspartate (NMDA)IBA 03/2010
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 03/2010
1	eglumetadIBA 04/2007
1	LY 379268IBA 04/2007
1	HexanesIBA 04/2007
1	Dopamine Receptors (Dopamine Receptor)IBA 01/2007
1	Mirtazapine (Rexer)FDA LinkGeneric 02/2003
1	MianserinIBA 02/2003
1	Risperidone (Risperdal Consta)FDA LinkGeneric 02/2003
1	Olanzapine (Zyprexa)FDA Link 02/2003

Therapy/Procedure

2	Therapeutics 04/2007 - 01/2007